You already know that a solid treatment plan for depression isn’t just a documentation requirement - it’s the difference between reactive care and intentional, measurable progress. When you build a treatment plan that’s precise, trackable, and grounded in evidence, you give yourself and your patient a shared roadmap that clarifies next steps and catches early signs of stagnation or risk.
Here’s the thing: most of us learned treatment planning in grad school as a bureaucratic exercise, not as a clinical tool. But when you structure it right - matching severity to care level, setting SMART goals, tracking outcomes with validated measures - it becomes one of your most powerful instruments for coordination, accountability, and flexibility. If that resonates, this guide will walk you through each component with the specificity you need to implement it tomorrow.
TL;DR
- A treatment plan for depression is a structured, written document that includes DSM-5-TR diagnosis, severity stratification, SMART goals, evidence-based interventions, safety planning, and measurement schedules.
- Match level of care to severity: Mild depression often responds to guided self-help and behavioral activation; moderate depression benefits from therapy, medication, or both; severe depression or high-risk presentations require combination therapy and possible specialty referral.
- Use measurement-based care: Track PHQ-9 scores every 2-4 weeks to define response (50% reduction) and remission (minimal symptoms), and adjust interventions by week 4-6 if progress stalls.
- Safety planning is non-negotiable: Document risk level, protective factors, warning signs, internal coping strategies, supports, means restriction, and crisis contacts at every visit during acute phases.
- Adjust fast when stuck: If no improvement by 4-6 weeks at therapeutic dose, switch medication classes, augment, increase therapy frequency, or consult psychiatry - don’t wait for passive deterioration.
What a Treatment Plan for Depression Includes
A treatment plan for depression is a written, shared roadmap that organizes your clinical thinking and gives both you and your patient clarity on diagnosis, goals, interventions, and follow-up. Its purpose is straightforward: reduce depressive symptoms, restore everyday functioning, ensure safety, and support relapse prevention. You build it collaboratively with your mental health team, review it regularly, and adjust it as data and context change.
Every effective treatment plan includes a few core components. You start with a DSM-5-TR diagnosis of major depressive disorder and relevant specifiers - anxious distress, melancholic features, seasonal pattern, and so on.
You document severity using a validated measure like the PHQ-9, which also guides your level-of-care recommendation. Next, you define SMART goals tied to symptom reduction and functional outcomes, then list evidence-based interventions with clear modality, frequency, and responsible clinician.
You layer in a safety plan, schedule for measurement and review, and notes on care coordination, consent, and patient preferences. This structure keeps the plan actionable, not aspirational.
Assessment and Differential: Build a Precise Starting Point
Screen, Diagnose, and Rule Out
You can’t build a useful treatment plan without a solid diagnostic foundation. Start with the PHQ-9 to establish severity and baseline - it’s quick, validated, and tracks the nine diagnostic criteria for major depressive disorder.
Confirm diagnosis using the SIGECAPS mnemonic: sleep disturbance, loss of interest, excessive guilt or worthlessness, energy loss, concentration problems, appetite change, psychomotor agitation or retardation, and suicidal ideation. At least two weeks of symptoms with functional impairment and clinically significant distress seals it.
Don’t skip bipolar disorder screening when the history or presentation raises flags - recurrent episodes, family history, early onset, or atypical features like hypersomnia and leaden paralysis. Use the Mood Disorder Questionnaire (MDQ) as a quick screen.
Check for psychotic symptoms, mixed features (elevated energy or irritability alongside depressed mood), and atypical presentations that shape intervention choice and prognosis.
Risk and Safety Assessment
Ask directly about suicidal ideation, intent, plan, and access to means every time risk is present or severity is moderate or higher. Vague check-ins miss critical details. Use a structured tool like the Columbia-Suicide Severity Rating Scale (C-SSRS) to standardize your assessment and document thoroughly.
Record protective factors - reasons for living, social supports, engagement in care - and acute stressors like job loss, relationship issues, or medical diagnosis.
Medical and Medication Contributors
Clinical depression has many medical mimics and contributors, so review thyroid function, anemia, vitamin D deficiency, sleep apnea, and chronic pain conditions. Screen for substances and medications that affect mood: corticosteroids, isotretinoin, beta-blockers, benzodiazepines, and alcohol or cannabis use.
Don’t overlook perinatal states and hormonal transitions - postpartum, perimenopausal, and post-weaning periods carry elevated risk and may require specialized care coordination with OB or endocrinology through a collaborative care model.
Stratify Severity and Match Level of Care
Severity stratification isn’t just for documentation - it directly drives your intervention intensity and care setting. Use PHQ-9 score ranges alongside functional impact to assign a severity category, then match that category to appropriate care options.
Severity Categories
- Mild depression: PHQ-9 score 5-9, with modest functional impact - work and relationships are strained but intact.
- Moderate depression: PHQ-9 score 10-14, with clear impairment in daily functioning at home, work, or school.
- Moderately severe to severe depression: PHQ-9 score 15-27, with high functional impairment and possible suicidal ideation or intent.
Level of Care Recommendations
- Mild: Start with guided self-help CBT modules, behavioral activation, exercise prescription (150 minutes per week of moderate exercise), and close monitoring every 2-4 weeks or watchful waiting in some cases.
- Moderate: Offer individual psychotherapy (cognitive behavioral therapy, interpersonal therapy, or behavioral activation) plus an SSRI or SNRI, or either modality based on patient preference and prior treatment history.
- Severe or high risk: Combine psychotherapy and antidepressant medication, increase visit frequency to weekly or more, involve supports with consent, and consult psychiatry for medication management or specialty modalities.
- Psychosis, catatonia, or imminent risk: Urgent psychiatric evaluation, possible hospitalization, and consideration of electroconvulsive therapy (ECT) for rapid stabilization.
Severity-to-Care Matching Table
Severity | PHQ-9 Range | Functional Impact | Recommended Care |
|---|---|---|---|
Mild | 5-9 | Modest impairment | Guided self-help, BA, exercise, monitoring |
Moderate | 10-14 | Clear impairment | Therapy + medication, or either based on preference |
Moderately Severe | 15-19 | High impairment | Combination therapy, weekly visits, safety planning |
Severe | 20-27 | Severe impairment, possible risk | Combination therapy, frequent contact, psychiatry consult |
With psychosis/imminent risk | Variable | Critical impairment | Urgent psychiatric care, hospitalization, ECT consideration |
Set SMART Goals and Measurable Objectives
SMART goals - Specific, Measurable, Achievable, Relevant, and Time-bound - transform vague intentions into trackable outcomes. You establish clear treatment goals tied to depression symptoms, function, and the patient’s values, then break them into short-term objectives that you can measure at each visit or review point.
Examples of Measurable Objectives
- Reduce PHQ-9 score from 18 to 9 or below within 8 weeks.
- Attend 8 weekly cognitive behavioral therapy sessions, then transition to biweekly sessions for 4 additional visits.
- Complete a behavioral activation activity schedule at least 4 days per week for 6 consecutive weeks.
- Achieve a consistent sleep window of 7-8 hours within 4 weeks using sleep hygiene and stimulus control.
- Report zero days of suicidal intent for 4 consecutive weeks by end of month 2.
- Take prescribed antidepressant medication at least 6 days per week, verified by pill counts or electronic medication adherence records.
These objectives give you and your patient concrete markers to celebrate progress or recognize when the treatment plan needs adjustment. They also make insurance reviews and case consultations straightforward for mental health professionals.
Evidence-Based Interventions by Severity
Evidence-based care for depression in adults starts with the right match between intervention intensity and patient severity. You layer psychotherapy, medication, lifestyle interventions, and specialty modalities based on symptom burden, risk level, and treatment history.
Psychotherapies with Strong Evidence
- Cognitive Behavioral Therapy (CBT): Targets negative thought patterns, behavioral avoidance, and skill deficits through structured sessions and homework using cognitive restructuring techniques.
- Behavioral Activation (BA): Focuses on scheduling rewarding and values-aligned activities to counter withdrawal and anhedonia.
- Interpersonal Psychotherapy (IPT): Addresses grief, role disputes, life transitions, and interpersonal deficits that trigger or maintain depression.
- Psychodynamic Therapy: Explores unconscious patterns, affect regulation, and relational themes that contribute to depressive symptoms through psychodynamic psychotherapy techniques.
- Mindfulness-Based Cognitive Therapy (MBCT): Prevents relapse in patients with recurrent depression by teaching awareness and decentering from negative thoughts.
- Supportive Therapy: Builds therapeutic alliance, coping skills, and adaptive problem-solving when more structured modalities aren’t tolerated or indicated.
Intervention Matching by Severity
Severity Level | First-Line Interventions | Frequency | Add-Ons |
|---|---|---|---|
Mild | Psychoeducation, guided self-help CBT, BA, exercise | Every 2-4 weeks | Sleep hygiene, monitoring |
Moderate | CBT or IPT, SSRI/SNRI, or combination | Weekly therapy, daily medication | Activity scheduling, social support |
Severe | Combination therapy (CBT + medication), safety planning | Weekly or more, daily medication | Psychiatry consult, TMS, ECT if needed |
Treatment-Resistant | Switch or augment medication, increase therapy intensity | Twice weekly or more | Lithium, atypical antipsychotic, ECT, TMS |
Mild Depression: First-Line Steps
For mild depression cases, start with psychoeducation and active monitoring using PHQ-9 every 2-4 weeks. Offer guided self-help CBT modules - many are free or low-cost online - or internet-delivered CBT techniques with brief clinician support.
Behavioral activation is particularly efficient: you help the patient create specific activity lists tied to values and schedule them daily. Prescribe aerobic physical activity at 150 minutes per week of moderate intensity, and improve sleep hygiene with consistent wake times and stimulus control techniques.
Moderate Depression: Therapy, Medication, or Both
Moderate depression in adults responds well to structured psychotherapy - 12 to 20 therapy sessions of cognitive behavioral therapy or interpersonal psychotherapy on average - or to first-line selective serotonin reuptake inhibitors (SSRIs) like sertraline, escitalopram, or fluoxetine.
Many patients do best with combination therapy from the start, which improves response rates and reduces relapse risk. Let patient preference, prior treatment history, and side-effect profile guide the choice, and document the rationale clearly in clinical practice.
Severe Depression: Combination and Specialty Options
Cases of severe depression require combination therapy upfront: weekly psychotherapy plus daily medication, with close safety monitoring at every visit. To treat severe depression effectively, involve family or other supports when the patient consents, and coordinate with psychiatry early if response lags or risk escalates.
For patients with psychotic symptoms, severe psychomotor slowing, or acute suicidality requiring rapid response, consider electroconvulsive therapy (ECT). Transcranial magnetic stimulation (TMS) is an option for treatment-resistant depression without psychosis, particularly when patients decline or can’t tolerate ECT.
Medication Essentials: Selection and Monitoring
Common first-line agents include sertraline, escitalopram, fluoxetine (selective serotonin reuptake inhibitors or SSRIs), and venlafaxine or duloxetine (serotonin norepinephrine reuptake inhibitors or SNRIs). Bupropion is useful for patients with low energy, hypersomnia, or concerns about sexual side effects, but avoid it in anyone with seizure risk.
Mirtazapine helps with insomnia and low appetite but monitor for sedation and weight gain. Some adults treatment protocols also consider tricyclic antidepressants for specific cases, though they require careful blood pressure monitoring.
Review the black-box warning on suicidality in patients under 25 and monitor closely during the first 4-6 weeks and after any dose change using the same dose escalation schedule. Check for side effects, adherence barriers, drug-drug interactions, and contraindications at every visit.
If there’s no response by 4-6 weeks at a therapeutic dose, don’t wait - switch medication classes or augment with bupropion, mirtazapine, lithium, or an atypical antipsychotic medication as appropriate.
Treatment-Resistant Depression: Next Steps
When depression doesn’t respond to two adequate trials of different-class antidepressants, confirm the diagnosis, rule out bipolar disorder and comorbid conditions, and assess adherence. Switch to a different class - SSRI to SNRI, for example, or consider tricyclic antidepressants - or augment with an agent that has evidence for adjunctive use. Consult psychiatry for complex cases and discuss TMS or electroconvulsive therapy if appropriate.
Safety Planning and Risk Management
Create a Brief, Actionable Safety Plan
Every patient with moderate-to-severe depression or any level of suicidal ideation needs a written safety plan that they can access quickly during crisis moments. Include these components:
- Warning signs and triggers: Specific thoughts, feelings, or situations that signal escalating risk.
- Internal coping strategies: Actions the patient can take alone - breathing exercises, distraction techniques, grounding skills, mindfulness exercises, and relaxation techniques.
- People and places for distraction and support: Friends, family, or public settings that reduce isolation and provide relief.
- Contact information: Phone numbers for trusted supports, your office, and backup mental health professionals.
- Means safety and restriction steps: Remove or secure firearms, medications, and other lethal means.
- Crisis resources: 988 Suicide and Crisis Lifeline, local mobile crisis teams, and nearest emergency department.
Monitoring and Documentation
Record risk level, protective factors, and safety plan updates in every progress note during acute phases. Increase contact frequency - twice weekly or more - when risk rises or life stressors intensify. Coordinate with family, partners, or other supports when the patient consents, and document those conversations thoroughly to demonstrate care continuity and shared responsibility across your mental health team.
Comorbidities, Specifiers, and Special Populations
Common Comorbidities
Anxiety disorders, PTSD, OCD, and panic frequently co-occur with major depressive disorder and require integrated treatment - don’t assume treating depression alone will resolve the anxiety. Substance use disorders complicate pharmacotherapy and increase dropout risk, so address cravings, withdrawal, and harm reduction early.
ADHD, eating disorders, and cluster B or C personality traits affect engagement, pacing, and therapeutic alliance - adjust your expectations and interventions accordingly.
Specifiers and Course Features
DSM-5-TR specifiers shape prognosis and treatment selection. Melancholic features (early morning awakening, psychomotor changes, anhedonia) often predict better medication response.
Atypical features (hypersomnia, hyperphagia, leaden paralysis, rejection sensitivity) may respond better to MAOIs or SSRIs, though MAOIs are rarely first-line due to dietary restrictions.
Mixed features - depressed mood with elevated energy or irritability - raise the possibility of bipolar spectrum illness and warrant caution with antidepressants alone. Persistent depressive disorder (dysthymia) may benefit from Cognitive Behavioral Analysis System of Psychotherapy (CBASP) or combined medication and therapy over extended timelines for depression treatment.
Special Populations
Perinatal patients require careful screening for a major depressive episode, collaborative decision-making around medication safety in pregnancy and lactation, and close coordination with obstetrics.
Adolescents need family therapy sessions, school-based coordination, and heightened monitoring for suicidality given developmental risk factors.
Older adults face higher medical burden, drug-drug interactions, cognitive changes, and fall risk from sedating medications - start low and go slow in adults treatment.
Cultural and linguistic factors matter: adapt materials, involve interpreters, and connect patients to culturally congruent community supports and peer networks recommended by the Department of Health and Human Services.
Lifestyle and Social Determinants in the Plan
Sleep and Circadian Routine
- Establish a consistent sleep window and wake time, even on weekends.
- Use stimulus control: bed is for sleep and sex only, not screens or rumination.
- Address insomnia with CBT-I strategies - sleep restriction, cognitive restructuring techniques, and relaxation training - before adding sedating medications to improve sleep hygiene.
Activity, Diet, and Substances
- Prescribe regular aerobic physical activity - walking, swimming, cycling - at least 150 minutes per week at moderate intensity.
- Encourage balanced meals, hydration, and reduced caffeine intake after mid-afternoon.
- Reduce alcohol and cannabis use, which worsen mood stability, sleep architecture, and medication efficacy.
Supports and Stressors
- Map the patient’s social supports and connect them to peer support groups, community organizations, or faith-based networks.
- Address social determinants directly: housing instability, food insecurity, unemployment, and discrimination all predict worse outcomes and require referrals to case management, benefits enrollment through Health and Human Services programs, or legal aid.
Measurement-Based Care and Follow-Up
Tools and Cadence
Use the PHQ-9 or Beck Depression Inventory at baseline and every 2-4 weeks throughout depression treatment. Track anxiety symptoms with the GAD-7 if comorbid anxiety is present. Monitor medication side effects with a brief checklist - sexual dysfunction, weight change, sedation, and gastrointestinal upset are the most common complaints with serotonin reuptake inhibitors SSRIs and SNRIs.
Define Progress and Outcomes
Response means at least 50% reduction in symptom severity from baseline - a drop from PHQ-9 of 18 to 9, for example, indicating reduced depressive symptoms.
Remission means minimal residual symptoms and restored functioning, typically a PHQ-9 score below 5.
Relapse is the return of full depressive symptoms after a period of remission, signaling the need for treatment intensification or maintenance therapy focused on relapse prevention.
Modify the Plan Based on Data
If there’s no meaningful improvement by 4-6 weeks at a therapeutic medication dose using clinical judgment, adjust: increase the dose, switch to a different class, or add psychotherapy if the patient was on medication alone.
When psychotherapy alone isn’t working to reduce depressive symptoms, add medication or increase session frequency. Shorten follow-up intervals when severity or risk increases, and lengthen them gradually as the patient stabilizes and enters the maintenance phase.
Documentation, Coordination, and Ethics
Document Clearly
Record the DSM-5-TR diagnosis of major depressive disorder with relevant specifiers, PHQ-9 score, functional impairment, and risk assessment in every progress note. Document informed consent for psychotherapy and medications, including discussion of side effects, black-box warnings, and alternatives. Note the rationale for any treatment plan changes and set a clear next review date so the plan stays active, not static.
Coordinate Care
Share updates with the primary care provider, psychiatrist, occupational therapists, or school counselor when the patient consents. Clarify roles: who prescribes, who provides formal therapy, who monitors labs or medical comorbidities. Establish frequency and mode of communication - secure email, phone check-ins, or shared electronic health record - and document every care coordination contact across your mental health team.
Ethical Notes
Review confidentiality limits at the start of treatment and whenever risk escalates. Your duty to protect kicks in when there’s imminent risk of harm to self or others, and documentation of that decision-making is critical. Practice cultural humility: ask about identity, language, values, and community, and adapt your interventions and materials to fit the patient’s context rather than expecting them to fit yours.
Example Template: Comprehensive Depression Treatment Plan
Use this fill-in structure to organize your next treatment plan:
- Problem list and strengths: Current depression symptoms, comorbidities, functional impairments, and patient strengths or protective factors.
- Diagnosis and specifiers: Major depressive disorder, recurrent, moderate, with anxious distress (example).
- Severity rating: PHQ-9 score of 16 at baseline.
- Long-term goals: Return to full-time work within 10 weeks; restore daily functioning and social engagement; establish clear treatment goals.
- Short-term objectives: Reduce PHQ-9 from 16 to 8 or below within 8 weeks; attend 8 weekly CBT therapy sessions; complete 3 pleasant activities per week for 6 weeks; take medication 6+ days per week.
- Interventions: Weekly individual cognitive behavioral therapy for 8-12 sessions (Therapist Name); sertraline 50 mg daily, increase to 100 mg at week 4 if tolerated (Prescriber Name).
- Medication plan: Sertraline 50 mg daily for 4 weeks, then increase to 100 mg if partial response; monitor side effects and adherence weekly.
- Safety plan summary: Warning signs documented; internal coping strategies (breathing, distraction); support contacts (partner, friend); means restriction (firearms secured off-site); crisis line: 988.
- Measurement schedule: PHQ-9 every 2 weeks; GAD-7 at weeks 0, 4, and 8.
- Review date: 8 weeks from baseline; sooner if risk increases or no improvement by week 4.
- Care coordination and consent: Consent signed to share updates with PCP; psychiatry consult available if no response by week 6.
Examples of Concise Goals and Objectives
- Goal: Return to work full-time within 10 weeks.
- Objective: Reduce PHQ-9 score from 18 to 9 or less within 8 weeks to reduce depressive symptoms.
- Objective: Complete 3 pleasant activities per week for 6 consecutive weeks using coping skills.
- Objective: Attend 8 weekly therapy sessions over 8-10 weeks.
When to Adjust, Switch, or Escalate Care
You can’t wait for passive deterioration. If the data or clinical picture signals stagnation or worsening, act fast.
Indicators for Change
- Minimal or no improvement by 4-6 weeks at a therapeutic medication dose.
- Intolerable side effects that impair adherence or quality of life.
- Emergent suicidality, psychotic symptoms, or manic or hypomanic features.
- New or worsening functional impairment despite adherence to the current treatment plan.
Next-Step Options
- Switch medications: Move within the same class (sertraline to escitalopram) or across classes (SSRI to SNRI or bupropion).
- Augment: Add bupropion for energy, mirtazapine for sleep and appetite, lithium for treatment resistance, or an antipsychotic medication like aripiprazole or quetiapine when appropriate as antidepressant and antipsychotic medication combination.
- Increase therapy intensity: Move from biweekly to weekly sessions, add family therapy sessions, or add group therapy or skills training.
- Consult psychiatry: For medication management, diagnostic clarification, or consideration of TMS or ECT.
Don’t let inertia or hope substitute for data-driven adjustment. If the treatment plan isn’t working by week 4-6, change it.
Patient Education and Reliable Resources
Handouts and Self-Help Tools
- CBT and behavioral activation worksheets from evidence-based sources like the Centre for Clinical Interventions or Beck Institute.
- Behavioral activation calendars and mood logs to track activities and their impact on depressed mood.
- Sleep hygiene and CBT-I handouts for patients with insomnia following clinical practice guidelines.
Support and Crisis Resources
- 988 Suicide and Crisis Lifeline: 24/7 phone, text, and chat support for acute suicidal ideation or emotional crisis.
- NAMI (National Alliance on Mental Illness): Education programs, support groups, and helpline for patients and families.
- SAMHSA Treatment Locator: Directory of mental health and substance use treatment services through Health and Human Services.
Digital Tools
- Evidence-based CBT apps like MoodKit or Woebot for between-session support to treat depression.
- Mood tracking apps like Daylio or Moodpath to visualize patterns and triggers.
- Encourage limited, structured use - review app data together in session to reinforce insights and avoid self-diagnosis or anxiety spirals.
Conclusion
A strong treatment plan for depression is specific, measurable, and flexible. You start with precise assessment and severity stratification, set aligned SMART goals, match evidence-based psychodynamic therapy, cognitive behavioral therapy, interpersonal therapy, supportive therapy, or other modalities and medication to the patient’s clinical picture, and track outcomes with validated measures every 2-4 weeks.
You document thoroughly, coordinate across providers, center safety planning at every visit, and adjust fast when progress stalls.
This structure transforms the treatment plan from a compliance document into a clinical tool that drives decision-making, accountability, and collaboration. Review it often so the plan evolves as the patient’s depression symptoms, function, and life circumstances change. That’s how you move from reactive care to intentional, trackable recovery focused on relapse prevention.
FAQs: Treatment Plan for Depression
What is a treatment plan for depression, and why does it matter?
A treatment plan for depression is a written document that organizes diagnosis of major depressive disorder, severity, goals, evidence-based interventions, safety planning, and outcome measurement. It matters because it clarifies next steps, tracks progress with objective data, and ensures coordinated care across mental health professionals.
How do I match severity to level of care in a depression treatment plan?
Use the PHQ-9 score and functional impairment to stratify severity. Mild depression (PHQ-9 5-9) responds to guided self-help and behavioral activation; moderate depression (10-14) benefits from therapy, medication, or both; severe depression (15-27) requires combination therapy, frequent contact, and possible specialty referral to treat severe depression effectively.
What are SMART goals for depression treatment?
SMART goals are Specific, Measurable, Achievable, Relevant, and Time-bound. Examples include: reduce PHQ-9 from 18 to 9 within 8 weeks; attend 8 weekly therapy sessions; complete a behavioral activation schedule 4 days per week for 6 weeks using coping skills.
Which psychotherapy approaches have the strongest evidence for depression?
Cognitive behavioral therapy (CBT), behavioral activation (BA), and interpersonal psychotherapy (IPT) have the most robust evidence. Psychodynamic psychotherapy and Mindfulness-Based Cognitive Therapy (MBCT) for relapse prevention also show strong support in specific populations to treat depression.
When should I consider switching or augmenting antidepressant medication?
If there’s no meaningful improvement by 4-6 weeks at a therapeutic dose, switch to a different class - like tricyclic antidepressants - or augment with bupropion, mirtazapine, lithium, or an antipsychotic medication. Don’t wait longer - early adjustment improves long-term outcomes in depression in adults.
How often should I use the PHQ-9 in a depression treatment plan?
Administer the PHQ-9 at baseline and every 2-4 weeks throughout active treatment to reduce depressive symptoms. This measurement-based care approach lets you define response (50% reduction), track remission (PHQ-9 below 5), and adjust interventions when progress stalls.
What belongs in a safety plan for a depressed patient?
Include warning signs, internal coping strategies (breathing exercises, relaxation techniques), people and places for support, contact information for mental health professionals and crisis services, means restriction steps (secure firearms and medications), and the 988 Suicide and Crisis Lifeline number.
How do comorbidities affect a depression treatment plan?
Anxiety disorders, PTSD, substance use disorders, and ADHD require integrated treatment. Don’t assume treating major depression alone resolves comorbid conditions - screen, assess, and address each diagnosis with tailored interventions following diagnostic criteria.
What are the first-line medication options for moderate to severe depression?
Selective serotonin reuptake inhibitors (SSRIs) like sertraline, escitalopram, and fluoxetine, or serotonin norepinephrine reuptake inhibitors (SNRIs) like venlafaxine and duloxetine are first-line. Bupropion is useful for low energy and avoiding sexual side effects. Mirtazapine helps with insomnia and appetite loss but monitor for sedation and weight gain.
When should I refer to psychiatry or consider ECT or TMS?
Refer to psychiatry when there’s minimal response to two adequate medication trials, emergent mania or psychotic symptoms, or complex comorbidities. Consider electroconvulsive therapy (ECT) for severe depression, psychotic depression, or high-risk major depressive episode needing rapid response. TMS is an option for treatment-resistant cases without psychosis when ECT is declined or contraindicated.
